- Open Access
Dermoid cyst of the pancreas: presentation and management
© Tucci et al; licensee BioMed Central Ltd. 2007
- Received: 31 March 2007
- Accepted: 03 August 2007
- Published: 03 August 2007
Dermoid cyst of the pancreas is a benign, well-differentiated, extremely rare germ cell neoplasm. Published data indicate that differential diagnosis of cystic lesions of the pancreas is challenging and although ultrasonography, computed tomography and magnetic resonance may be useful, radiological findings are often inconclusive and the diagnosis is intraoperative. We report a case of a dermoid cyst of the tail of the pancreas intraoperatively diagnosed and successfully treated with left pancreatectomy. Further, characteristics, preoperative detection and differential diagnosis of this rare pathology are also discussed.
This report documents the findings of a 64-year-old male presenting with a well defined echogenic pancreatic mass on ultrasonography. Computerized Tomography (CT) showed a 5 cm cystic tumor arising from pancreatic tail and Magnetic Resonance Imaging (MRI) suggested a tumor extension to the middle side of the stomach without defined margins. A left pancreatectomy was performed. On surgical specimen, histological evaluation revealed a dermoid cyst of the tail of the pancreas measuring 8.5 × 3.0 cm.
Given the benign nature of the dermoid cyst, surgical resection most likely represents the definitive treatment and cure. In addition, resection is indicated in consideration of the difficulty in diagnosing dermoid cyst preoperatively. However, endoscopic ultrasound and fine needle aspiration cytology have recently been shown to be effective, safe, reliable and cost-saving preoperative diagnostic tools. Therefore, until more cases of dermoid cyst are identified to further elucidate its natural history and improve the reliability of the preoperative diagnostic tools, surgical resection should be considered the standard therapy in order to exclude malignancy.
- Cystic Lesion
- Dermoid Cyst
- Epidermoid Cyst
- Islet Cell Tumor
Dermoid cyst of the pancreas, also called cystic teratoma, constitutes an unusual entity with only 21 cases, to our knowledge, described in the world literature [1–21]. Mature cystic teratoma of pancreas was first described in 1918 by Kerr  and, in 1922, it was included by Primrose in the classification of cystic pancreatic lesions .
They can be classified as benign, well-differentiated lesions, which are solid or cystic, and solid malignant undifferentiated tumors, named, respectively, mature and immature teratomas on the basis of the presence of immature neuroectodermal elements within the tumour .
Mature cystic teratoma is commonly found in the ovary, but may occur in any pathway of ectodermal cell migration, typically in the midline, such as testes, cranium, brain, mediastinum, omentum, retroperitoneum and sacrococcygeal regions. Besides, pancreas is extremely rare as primary site .
Clinical presentation of pancreatic dermoid cyst is non specific. Complaints at presentation include abdominal pain, back pain, nausea, vomiting, anorexia, weight loss, fatigue, fever and finally some cases can be diagnosed during a work-up for other diseases [14, 20, 21].
Dermoid cyst of the pancreas is a true cyst, thus the cyst wall consists of stratified squamous epithelium and underlying connective tissue. At macroscopical evaluation, the cyst contains differentiated tissues from one or more germ cell layers, usually ectodermal; the cyst content appears pasty, "cheesy" or "caseous", with keratinaceous and sebaceous secretions, and it rarely may be clear and serous. Microscopically, the cyst is lined by stratified squamous epithelium and immediately adjacent, dense sub epithelial lymphoid tissue that contains lymphoid follicles and germinal centers.
Differential diagnosis of lesions that mimic cystic neoplasms of the pancreas is still difficult and it is especially hard to differentiate among pancreatic cystic neoplasms. Even though Ultrasonography (US), CT and MRI may be helpful, there are no pathognomonic data for their preoperative recognition.
The diagnostic approach in such patients is debated. Some observers emphasize the difficulties in achieving a diagnosis of certitude without resection, whereas others choose to determine the need for surgery based on the results of Endoscopic Ultrasound (EUS) coupled with US, CT or EUS-guided FNA cytology and histology .
Treatment of dermoid cysts consists of surgical removal; clinical observation has not been reported. Surgical procedures previously reported in literature are external drainage in 5 patients, more recently abandoned in consideration of postoperative chronic draining fistula , cystectomy in 12; distal pancreatectomy in two (one plus splenectomy) and cystogastrectomy in one case [1–21].
The authors present a case report of a 64-year-old man with a pancreatic dermoid cyst intraoperatively diagnosed; furthermore preoperative detection, differential diagnosis and management of pancreatic dermoid cysts are also discussed.
Pancreatic cystic lesions comprise a pathologically heterogeneous group of lesions that can be classified as congenital, inflammatory, and neoplastic and share many common clinical features. Identification of the different cystic lesions is still inadequate. There is ample debate regarding the diagnostic approach in such patients. Some observers consider the diagnosis intraoperative, whereas others choose to determine the need for surgery based on the results of biochemical and tumor markers in the cystic fluid obtained by CT or EUS-guided FNA.
Differential diagnosis of pancreatic dermoid cysts from the other two types of pancreatic cysts lined by squamous epithelium, e.g. lymphoepitelial cysts and epidermoid cyst, may be difficult preoperatively.
Dermoid cysts usually occur in a younger age group, and in contrast with lymphoepitelial cysts, which are more common in men, there is no gender predominance. Furthermore, mucinous epithelium, respiratory-type mucosa, sebaceous units and hair follicles are more readily identifiable in dermoid cysts rather than in lymphoepitelial or epidermoid cysts. Finally suppurative infections are more frequent in dermoid cysts rather than in other "squamous-lined" pancreatic cysts .
Given the absence of any known malignant potential of the above mentioned lesions, differential diagnosis between dermoid cyst and primary neoplastic cysts of the pancreas (e.g. mucinous cystic neoplasms, intraductal papillary mucinous neoplasms and intraductal oncocytic papillary neoplasms) appears more clinically significant.
The traditional serum markers, such as CEA and CA19-9, would be expected to be significantly lower in dermoid cysts rather than in other pancreatic cystic neoplasms; however, our experience does not confirm this prediction .
It was suggested that the combined use of ultrasonography, enhanced computed tomography and magnetic resonance cholangiopancreatography might allow differentiation from cystic lesions such as mucinous cystic tumors and intraductal papillary-mucinous tumors. Since cystic teratomas enclose keratinous and sebaceous material, they are echogenic, appearing as solid masses on US. Enhanced CT shows their cystic nature, with values slightly higher than water, and MRCP reveals defects of internal signals .
Moreover, the differential diagnosis of dermoid cysts from the rare cystic forms of solid pancreatic tumors (solid pseudopapillary tumors, ductal adenocarcinomas, cystic islet cell tumors, and acinar cell cystadenocarcinoma) is a clinical challenge .
Imaging may be not specific and the radiological appearance of these lesions differs according to the proportions of the various tissues enclosed in the cysts. CT accurately estimates the density of all the included tissues, such as soft tissue, fluid, fat, calcification, and teeth. MRI can also be performed for further characterization and study of anatomic relations [14, 20, 21].
Recently, EUS has been shown to have a high sensitivity to detect pancreatic masses. EUS-guided fine needle aspiration (FNA) cyto-histolology has been shown to be a safe, reliable and cost-effective tool to detect pancreatic masses, including malignant or benign neoplasms, pseudo cysts, and reactive changes. Pancreatic EUS-guided FNA cyto-histolology, coupled with the possibility of biochemical and tumor marker measurement in the cystic fluid, seems to allow an accurate and safe diagnosis without the risk, the cost, and the time expenditure of an open biopsy or laparotomy. A recent review about image-guided FNA biopsy of the pancreas revealed a relatively high overall sensitivity (64%–98%), specificity (80%–100%), and positive predictive value (98.4%–100%) .
Nevertheless, preoperative diagnosis of cystic lesions of the pancreas remains difficult, especially in presence of larger lesions (>3 cm), as suggested by Volmar  who reported, in a review of 1000 cases of US, TC or EUS-guided FNAC of pancreas, a false positive rate of 0.3% and a false negative rate of even 14.3% when compared with histology and clinical follow-up. In addition, the quality and the proper handling of the aspirated sample are crucial to the success of the diagnosis and the performance of biochemical and tumoral markers appears of limited help in the differential diagnosis of cystic lesions of the pancreas .
Further, the risk of cancer seeding along the needle tract during percutaneous sampling of pancreatic masses is noteworthy; the risk of peritoneal carcinomatosis appears to be lower with EUS-guided FNA compared with transcutaneous sampling methods .
Treatment of dermoid cysts, reported in previous experiences, consists of surgical removal; conservative treatment has not been described and, in most cases, cystectomy was performed [1–21]. Several factors interplay in the treatment choice: diagnostic accuracy of preoperative diagnostic tools, clinical presentation and type of symptoms, cystic neoplasm site, type and safety of resection.
It was suggested that conservative procedure, such as preservation of the pylorus in proximal pancreatectomy, segmental resection for isthmic/body tumors, and preservation of the spleen in distal pancreatectomy, is suitable to limit late sequelae. Simple cystic enucleation seems suitable for peripheral lesions, but very high rates of mortality and morbidity were reported in previous series . In a previous revision of the results of surgery for pancreatic serous cystadenoma, Pyke et al described complications that required reoperation in four of eight patients who underwent enucleation of the tumor without formal anatomic pancreatectomy. The routine use of prophylactic octreotide might be considered to decrease the high rate of pancreatic fistula. The decision to perform pancreatic resection is easier, as in our case, for body/tail tumors, which are not subject to surgical mortality, than for proximal cystic lesions, which have an operative mortality rate of up to 2% .
Given the benign nature of the dermoid cyst and considering the improvement in preoperative imaging together with the availability of FNA, that seems a promising tool for preoperative evaluation of pancreatic cystic lesions, it was suggested that if apt diagnoses were made, teratomas would not needed to be resected . Nevertheless, until more cases of dermoid cyst will be identified to further elucidate its natural history and improve the reliability of preoperative diagnosis, surgical resection should still be considered the standard therapy, in suitable patients, to exclude malignancy.
Written consent was obtained from the patient for publication of this case report.
- Kerr AA: Cysts and pseudocysts of the pancreas. Surg Gynecol Obstet. 1918, 27: 40-Google Scholar
- Dennis WA: Dermoid cyst of the pancreas. Surg Clin North Am. 1923, 3: 1319-Google Scholar
- Decourcy JL: Dermoid cyst of the pancreas. Ann Surg. 1943, 118: 394-10.1097/00000658-194309000-00007.PubMed CentralView ArticlePubMedGoogle Scholar
- Hoang-su , Nguyen-sang , Thon-that-tung : Case of teratomatous dermoid cyst (monstre endocymiere parasitaire) operated as pancreatic cyst. Pol Tyg Lek (Wars). 1956, 11: 1710-1713.Google Scholar
- Iovchev II: Suppurative dermoid cyst of the pancreas. Vestn Khir Im I I Grek. 1972, 107: 124-PubMedGoogle Scholar
- Pomosov DV, Shpit'ko FS, Volianiuk MA: Dermoid cyst of the pancreas in a child. Vestn Khir Im I I Grek. 1973, 110: 92-93.PubMedGoogle Scholar
- Assawamatiyanont S, King AD: Dermoid cysts of the pancreas. Am Surg. 1977, 43: 503-504.PubMedGoogle Scholar
- Lazaro da Silva A, Moreno M: Surgery of pancreatic dermoid cyst with ligature of superior mesenteric vein. Arq Gastroenterol. 1984, 21: 183-186.PubMedGoogle Scholar
- Bowen B, Ros PR, McCarthy MJ, Olmsted WW, Hjermstad BM: Gastrointestinal teratomas: CT and US appearance with pathologic correlation. Radiology. 1987, 162: 4313-View ArticleGoogle Scholar
- Mester M, Trajber HJ, Compton CC, de Camargo HS, de Almeida PC, Hoover HC: Cystic teratomas of the pancreas. Arch Surg. 1990, 125: 1215-1218.View ArticlePubMedGoogle Scholar
- Vermeulen BJ, Widgren S, Gur V, Meyer P, Iselin C, Rohner A: Dermoid cyst of the pancreas. Case report and review of the literature. Gastroenterol Clin Biol. 1990, 14: 1023-1025.PubMedGoogle Scholar
- Jentschura D, Bohrer MH, Geiger G: Para-pancreatic dermoid cyst. Chirurg. 1990, 61: 548-549.PubMedGoogle Scholar
- Markovsky V, Russin VL: Fine-needle aspiration of dermoid cyst of the pancreas: a case report. Diagn Cytopathol. 1993, 9: 66-69. 10.1002/dc.2840090114.View ArticlePubMedGoogle Scholar
- Jacobs JE, Dinsmore BJ: Mature cystic teratoma of the pancreas: sonographic and CT findings. AJR Am J Roentgenol. 1993, 160: 523-524.View ArticlePubMedGoogle Scholar
- Iacono C, Zamboni G, Di Marcello R, Zicari M, Maran M, Montresor E, Nicoli N, Serio G: Dermoid cyst of the head of the pancreas area. Int J Pancreatol. 1993, 14: 269-273.View ArticlePubMedGoogle Scholar
- Kraimps JL, Zins J, Levillain P, Azais O, Deleplanque G, Carretier M, Barbier J: Dermoid cyst of the pancreas. Eur J Surg. 1993, 159: 437-439.PubMedGoogle Scholar
- Fernandez-Cebrian JM, Carda P, Morales V, Galindo J: Dermoid cyst of the pancreas: a rare cystic neoplasm. Hepatogastroenterology. 1998, 45: 1874-1876.PubMedGoogle Scholar
- Chih-Wei Yu, Kao-Lang Liu, Wei-Chou Lin, Yiu-Wah Li: Mature cystic teratoma of pancreas in a child. Pediatric Radiology. 2003, Springer-Verlag, 101007/s00247-003-0872-2.Google Scholar
- Salimi J, Karbakhsh M, Dolatshahi S, Ahmadi SA: Cystic teratoma of the pancreas: a case report. Ann Saudi Med. 2004, 24: 206-209.PubMedGoogle Scholar
- Seki M, Ninomiya E, Aruga A, Yamada K, Koga R, Saiura A, Yamamoto J, Jamaguchi T, Takano K, Fujita R, Sasaki K, Kato Y: Image-diagnostic features of mature cystic teratomas of the pancreas: report on two cases difficult to diagnose preoperatively. J Hepatobiliary Pancreat Surg. 2005, 12: 336-340. 10.1007/s00534-005-0994-z.View ArticlePubMedGoogle Scholar
- Koomalsingh KJ, Fazylov R, Chorost MI, Horovitz J: Cystic teratoma of the pancreas: presentation, evaluation and management. JOP. 2006, 7: 643-646.PubMedGoogle Scholar
- Primrose A: Pancreatic cyst and pseudocyst. Surg Gynecol Obstet. 1922, 34: 431-436.Google Scholar
- Mishra G, Forsmark C: Cystic neoplasms of the pancreas. Current Treatment Options Gastroenterology. 2000, 3: 355-362. 10.1007/s11938-000-0050-7.View ArticleGoogle Scholar
- Adsay NV, Hasteh F, Cheng JD, Klimstra DS: Squamous-lined cysts of the pancreas: lymphoepithelial cysts, dermoid cysts (teratomas) and accessory-splenic epidermoid cysts. Semin Diagn Pathol. 2000, 17: 56-66.PubMedGoogle Scholar
- Micke O, Schafer U, Willich N: Persistent elevation of CA 19-9 levels in a patient with an extended retroperitoneal dermoid. Anticancer Res. 1999, 19: 2717-2720.PubMedGoogle Scholar
- Adsay NV, Hasteh F, Cheng JD, Bejarano PA, Lauwers GY, Batts KP, Klöppel G, Klimstra DS: Lymphoepithelial cysts of the pancreas: a report of 12 cases and a review of the literature. Mod Pathol. 2002, 15: 492-501. 10.1038/modpathol.3880553.View ArticlePubMedGoogle Scholar
- Antillon MR, Chang KJ: Endoscopic and endosonography guided fine-needle aspiration. Gastrointest Endosc Clin N Am. 2000, 10: 619-636.PubMedGoogle Scholar
- Volmar KE, Vollmer RT, Jowell PS, Nelson RC, Xie HB: Pancreatic FNA in 1000 cases: a comparison of imaging modalities. Gastrointest Endosc. 2005, 61: 854-861. 10.1016/S0016-5107(05)00364-0.View ArticlePubMedGoogle Scholar
- Micames C, Jowell PS, White R, Paulson E, Nelson R, Morse M, Hurwitz H, Pappas T, Tyler D, McGrath K: Lower frequency of peritoneal carcinomatosis in patients with pancreatic cancer diagnosed by EUS-guided FNA vs. percutaneous FNA. Gastrointest Endosc. 2003, 58: 690-695. 10.1016/S0016-5107(03)02009-1.View ArticlePubMedGoogle Scholar
- Pyke CM, Van Heerden JA, Colby TV, Sarr MG, Weaver AL: The spectrum of serous cystadenoma of the pancreas. Clinical, pathologic, and surgical aspects. Ann Surg. 1992, 215: 132-139. 10.1097/00000658-199202000-00007.PubMed CentralView ArticlePubMedGoogle Scholar
- Le Borgne J, De Calan L, Partensky C: Cystadenomas and Cystadenocarcinomas of the Pancreas. A Multiinstitutional Retrospective Study of 398 Cases. Ann Surg. 1999, 230: 152-161. 10.1097/00000658-199908000-00004.PubMed CentralView ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.