- Case report
- Open Access
Solitary Plasmacytoma of the Parotid Gland with Crystalline Inclusions: A Case Report
© Kanthan and Torkian; licensee BioMed Central Ltd. 2003
- Received: 14 May 2003
- Accepted: 01 August 2003
- Published: 01 August 2003
Solitary extramedullary plasmacytoma of the parotid gland is a rare condition. Intracytoplasmic Crystalline inclusions in the tumor are even rarer and have been reported only once in the parotid gland.
We report here, a case of plasmacytoma of the parotid gland with intracellular crystalline inclusions in a 73-year-old woman
Solitary extramedullary plasmacytoma of the parotid gland and crystalline inclusions in the tumor is of rare occurrence. The importance of such a finding with relation to tumor progression, clinical course of the disease or prognosis in general remains to be understood.
- salivary gland.
Review-published Cases of Parotid Plasmacytomas
1-Ustun MO et al. 
2-Hari CK, Roblin DG. 
3-Gonzalez-Garcia J et al. 
4-El-Naggar AK 
5-Kerr PD, Dort JC 
6-Rothfield RE et al. 
7-Simi U et al. 
8-Scholl P, Jafek BW 
9-Ebbers J 
10-Kanoh et al. 
11-Edney JA et al 
12-Ferlito A et al 
13-Pahor AL. 
14-Vainio-Mattila J 
Solitary primary extramedullary plasmacytomas are rare and found principally in elderly people. They occur predominantly in the head and neck area with a tendency to involve the submucosal tissues of the upper airway accounting for 0.5% of all upper respiratory tract neoplasms. In two third of the cases, these neoplasms are located in the upper respiratory tract or oral cavity primarily in the nose, sinuses and nasopharynx .
Histopathological analysis alone is not sufficient in order to make a diagnosis of primary extramedullary plasmacytoma as multiple myeloma must be excluded by a through skeletal and marrow workup, immuno-electrophoresis and quantitative immunoglobulins with absent urinary Bence Jones proteins. Fine needle aspiration cytology of plasmacytoma of the parotid gland is often reported unremarkable as in our case.
Treatment of solitary extramedullary plasmacytoma consists primarily of eradication of the local lesion and in this context surgery seems to be the primary line of treatment. Radiation therapy either alone in cases deemed unsuitable for surgery or as an adjunct with surgical removal has also been used. Local recurrences are also usually treated by radiation therapy  Although not proven, chemotherapy is theoretically advantageous, both in enhancing local control and in potentially eradicating sub-clinical disease to delay or prevent the development of myeloma. The patterns of relapse of primary extramedullary plasmacytoma include transformation to multiple myeloma, metastasis and local recurrence. Recurrences are usually local and respond well to radiation therapy. Combined chemotherapy and radiation therapy is recommended in high-risk patients to increase the local control rate and cure rate  In our case radiotherapy could have been added after surgery in order to eradicate residual tumor and to prevent local relapse. However, the validity of such adjuvant therapy with complete excision of the tumor with clear margins remains contradictory. Radiotherapy was administered in our case, upon local recurrence. The second local recurrence was managed by chemotherapy.
Crystalline inclusions composed of monoclonal immunoglobulins have been reported in multiple myeloma and lymphoproliferative disorders . A single publication of these crystalline inclusions in primary extramedullary plasmacytoma of the parotid gland has been reported by el-Naggar et al.  The crystals may be rectangular or square in shape, finely uniform or globular. Crystals can be stained with anti light and/or anti heavy chains of globulin, which often manifest a light chain restriction. They can be found in histiocytes, which absorb the immunoglobulins . The crystalline inclusions in our case were positive for IGg with Kappa restriction, confirming the intracellular crystallization of the immunoglobulin. Electron micrographs of the crystalline deposits show the polygonal, rectangular or diamond shape of this finding in solitary plasmacytoma. The importance of such a finding with relation to tumor progression, clinical course of the disease or prognosis in general remains uncertain.
Primary solitary extramedullary plasmacytoma of the parotid gland is of rare occurrence. Accurate diagnosis by fine needle aspiration requires a high index of suspicion. The presence of intracytoplasmic crystalline inclusions can further add confusion to the accurate pathological diagnosis of this entity especially at frozen section analysis.
RK is the surgical pathologist who diagnosed and followed-up this case and BT participated actively in the production of this manuscript.
The authors would like to thank Mr Todd Reichert and Michelle Hesson for their expert technical assistance in the production of the illustrations. Written consent was obtained from the patient for the use of all clinical material for research and publication.
- Booth JB, Cheesman AD, Vincenti NH: Extramedullary plasmacytomata of the upper respiratory tract. Ann Otol Rhinol Laryngol. 1973, 82: 709-715.View ArticlePubMedGoogle Scholar
- Vainio-Mattila J: Plasmacytoma of the parotid gland. Arch Otolaryngol. 1965, 82: 635-637.View ArticlePubMedGoogle Scholar
- Pahor AL: Extramedullary plasmacytoma of the head and neck, parotid and submandibular salivary glands. J Laryngol Otol. 1977, 91: 241-258.View ArticlePubMedGoogle Scholar
- Ferlito A, Polidoro F, Recher G: Extramedullary plasmacytoma of the parotid gland. Laryngoscope. 1980, 90: 486-493.View ArticlePubMedGoogle Scholar
- Edney JA, Thompson JS, Conley MC, Moore GE: Plasmacytoma of the parotid gland. J Surg Oncol. 1985, 28: 165-167.View ArticlePubMedGoogle Scholar
- Kanoh T, Hattori N, Uchino H, Fujita A, Ohmura M, Makimoto K: Extramedullary plasmacytoma of the parotid gland: report of a case and review of the literature. Tohoku J Exp Med. 1985, 146: 469-478.View ArticlePubMedGoogle Scholar
- Ebbers J: [Plasmacytoma of the parotid gland]. Laryngol Rhinol Otol (Stuttg). 1986, 65: 127-129.View ArticleGoogle Scholar
- Scholl P, Jafek BW: Extramedullary plasmacytoma of the parotid gland. Ear Nose Throat J. 1986, 65: 564-567.PubMedGoogle Scholar
- Simi U, Marchetti G, Bruno R, Di Nasso F, Cardini M: Plasmacytoma of the parotid gland. Report of a case and review of the world literature. Acta Otorhinolaryngol Belg. 1988, 42: 93-96.PubMedGoogle Scholar
- Rothfield RE, Johnson JT, Stavrides A: Extramedullary plasmacytoma of the parotid. Head Neck. 1990, 12: 352-354.View ArticlePubMedGoogle Scholar
- el-Naggar AK, Ordonez NG, Batsakis JG: Parotid gland plasmacytoma with crystalline deposits. Oral Surg Oral Med Oral Pathol. 1991, 71: 206-208.View ArticlePubMedGoogle Scholar
- Kerr PD, Dort JC: Primary extramedullary plasmacytoma of the salivary glands. J Laryngol Otol. 1991, 105: 687-692.View ArticlePubMedGoogle Scholar
- Gonzalez-Garcia J, Ghufoor K, Sandhu G, Thorpe PA, Hadley J: Primary extramedullary plasmacytoma of the parotid gland: a case report and review of the literature. J Laryngol Otol. 1998, 112: 179-181.View ArticlePubMedGoogle Scholar
- Hari CK, Roblin DG: Solitary plasmacytoma of the parotid gland. Int J Clin Pract. 2000, 54: 197-198.PubMedGoogle Scholar
- Ustun MO, Ekinci N, Payzin B: Extramedullary plasmacytoma of the parotid gland. Report of a case with extensive amyloid deposition masking the cytologic and histopathologic picture. Acta Cytol. 2001, 45: 449-453.View ArticlePubMedGoogle Scholar
- Tsang RW, Gospodarowicz MK, Pintilie M, Bezjak A, Wells W, Hodgson DC, Stewart AK: Solitary plasmacytoma treated with radiotherapy: impact of tumor size on outcome. Int J Radiat Oncol Biol Phys. 2001, 50: 113-120. 10.1016/S0360-3016(00)01572-8.View ArticlePubMedGoogle Scholar
- Suarez P, el-Naggar AK, Batsakis JG: Intracellular crystalline deposits in lymphoplasmacellular disorders. Ann Otol Rhinol Laryngol. 1997, 106: 170-172.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.